Genetics can play a real role in your risk for many diseases. Polygenic risk scores (PRS) factor in the cumulative impact of thousands of common genetic variants to estimate a person’s lifetime risk of developing complex diseases. Regardless of family history, PRS helps determine risk for conditions such as coronary artery disease, type 2 diabetes, atrial fibrillation, breast cancer, and Alzheimer’s disease. At SequenceMD, our polygenic risk score testing can help you understand your disease risk — enabling you to receive preventive, personalized care and make more informed health decisions.
Who Can Polygenic Risk Scoring Help?
- Healthy individuals interested in understanding their inherited disease risk
- Patients with strong lifestyle factors but unclear genetic risk
- Anyone unfamiliar with their family history (e.g., adopted, limited records)
- People with early-onset cardiovascular, metabolic, or neurodegenerative disease in family members
- Adults pursuing longevity medicine, preventive screening, or wellness planning
- Patients in primary care, cardiology, endocrinology, or concierge settings
Benefits of Doing a Disease Risk Analysis
- Understand risk for diseases like CAD, T2DM, obesity, AFib, breast cancer, prostate cancer, and Alzheimer’s disease
- Guide timing and frequency of health screenings (e.g., mammograms, coronary calcium)
- Inform preventive care strategies (e.g., statins, GLP-1 agonists, aspirin)
- Enable lifestyle changes based on individual risks
- Fill in health information gaps when family history is absent or ambiguous
Working with Your Full Care Team
The experts at SequenceMD have years of experience collaborating with primary care doctors and specialists to translate PRS and other genetic findings into actionable clinical guidance. SequenceMD will work with your providers and care team to:
- Provide evidence-based PRS testing with clear, structured interpretation
- Integrate polygenic risk scores with clinical and family history to guide surveillance
- Explain relative versus absolute risk for disease
- Coordinate next steps if elevated disease risk is found
- Support patients in making proactive health decisions
